Cenk Ayata , Kyu - Won

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury.

Oligodendrocyte precursor cells (OPCs) are thought to maintain homeostasis and contribute to long-term repair in adult white matter; however, their roles in the acute phase after brain injury remain unclear. Mice that were subjected to prolonged cerebral hypoperfusion stress developed white matter demyelination over time. Prior to demyelination, we detected increased MMP9 expression, blood-brai...

Spreading depression and neurovascular coupling.

Overhauser-enhanced MRI as a non invasive probe of BBB breakdown and redox state following ischemia/reperfusion

Overhauser-enhanced MRI as a non invasive probe of BBB breakdown and redox state following ischemia/reperfusion Matthew S. Rosen, Mathieu Sarracanie, Brandon D. Armstrong, Fanny Herisson, Najat Salameh, and Cenk Ayata Department of Radiology, MGH/Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, Department of Physics, Harvard University, Cambridge, MA, United ...

Age-related decline in oligodendrogenesis retards white matter repair in mice.

BACKGROUND AND PURPOSE Aging is one of the major risk factors for white matter injury in cerebrovascular disease. However, the effects of age on the mechanisms of injury/repair in white matter remain to be fully elucidated. Here, we ask whether, compared with young brains, white matter regions in older brains may be more vulnerable in part because of decreased rates of compensatory oligodendrog...

Neurobiology of Disease Migraine Mutations Impair Hippocampal Learning Despite Enhanced Long-Term Potentiation

Ergin Dilekoz,1* Thijs Houben,1,2* Katharina Eikermann-Haerter,1 Mustafa Balkaya,1 A. Mariette Lenselink,4 Michael J. Whalen,5 Sabine Spijker,4 Michel D. Ferrari,2 Arn M.J.M. van den Maagdenberg,2,3 and Cenk Ayata1,6 1Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, Departments of 2Neurology and...